Musi waNovember 9, 2021, mutsauko wecoronavirus itsvaB.1.1.529 yakaonekwa kekutanga kubva mumuenzaniso wenyaya yekuSouth Africa.Mumavhiki asingasviki 2, rudzi rwemutant rwakave rwakanyanya kuchinjika muSouth Africa yechirwere chekorona nyowani, uye kukura kwayo nekukurumidza kwakamutsa kutarisisa kwepasirese.Musi waMbudzi 26, rudzi urwu rwemutant rwakatsanangurwa neWHO sechishanu "mutsauko wekunetseka" (VOC), unonzi Omicron (Omicron) mutant.Parizvino, mhando yeOmicrom yakasiyana yakakurumidza kupararira kunyika 19 kana matunhu pasi rose, uye inogona kuunza denderedzwa idzva rematambudziko akanyanya kukudzivirira nekudzora denda repasi rose.
WHO yakataurawo kuti Omicron ine nhamba huru yekuchinja, mamwe acho ari kunetseka.WHO yakataurawo kuti "Omicron" mutant strain inoonekwa nekukasira kupfuura mamwe ma mutant strains akakonzeresa kuwedzera kwehutachiona munguva yakapfuura, zvichiratidza kuti iyi yazvino mutant dhizaini inogona kuve nemukana wekukura.Kunyatso kudzivirira kupararira kweiyo mutant dhizaini yekoronavirus Omicron yave chinangwa chitsva chekudzivirira denda repasi rose.
Mutation kugovera mepu yeOmicron(1）uye Delta(2）, Stanford University Coronavirus uye Drug Resistance Database
Pamusoro pekuve nekuchinja kwakawanda muprotein ye spike, iyo Omicron mutant strain ine zvakare akawanda masisitimu ekuchinja muN protein.Sezvo chinangwa chikuru cheiyo itsva coronavirus antigen yekuona reagent iri N protein, shanduko yeprotein yeN inogona kukanganisa iyo coronavirus antigen.Kurongeka kwetest kit kune chekuita.
| Tafura 1. Kufananidzwa kweN protein yekushandura yakasiyana-siyana
| |
| Rudzi rweutachiona
| N mapuroteni evolution |
| Alfa(B.1.1.7) | R203K;G204R;(>50%) S194L(5-50%) D3H;D63G;T205I;M234I(1-5%) |
| Beta(B.1.351) | T205I (>50%) P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| Gamma(p.1) | P80R;S202C;R203K;G204R (>50%) A211S;D402Y;S4131 (1-5%) |
| Delta(B.1.617.2) | D63G;R203M;G215C;D377Y (>50%) Q9L(>5-50%) G18V;R385K (1-5%)
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| Omicron(B.1.1.529) | P13L;R203K;G204R E31/R32/S33 Del |
Kuenzaniswa neAlpha-N protein, Omicron-N protein ine musiyano wegumi amino acid nzvimbo.Kuti tiongorore mabatirwo ekuita kweOmicron-N protein necovid-19 antibody raw material yeKeygen gene, takagadzira recombinant Omicron-N protein kekutanga, Uye takaita chibvumirano chekushandira pamwe neKeygen Gene uye vakati wandei vatengi.Mhedzisiro yacho inoratidza kuti iyo yakavhurika yekuona gene nyowani korona antibody zvinhu zvine zvakafanana zvekuonekwa mhedzisiro yezve recombinant Omicron-N protein, Alpha-N protein uye Delta-N protein.Iyo yakavhurika yekuona gene nyowani korona antibody zvinhu inogona kuve nechokwadi cheiyo koronavirus nyowani antigen kit yekuonekwa kweOmicron akasiyana..
| Tafura 2 Mibairo yekuonekwa kweOmicron recombinant N protein neocorona antibody | ||||||
| Antibody Paviri | Alpha-Nprotein | Omicron-Nprotein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Plan 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Plan 2 | G5 | G4 | G2 | G5 | G4 | G2 |
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Nguva yekutumira: Zvita-14-2021
